BI-3406 free base · Synonyms: BI 3406 · BI3406

BI-3406 is a Son of Sevenless 1 inhibitor.

For research use only. Not for human or veterinary use.

Target Others

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BI-3406 structure

CAS No.: 2230836-55-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 525.00	BP-01992-500mg	In stock	Get quote
1 g	USD 765.00	BP-01992-1g	In stock	Get quote
5 g	Inquire	BP-01992-5g	In stock	Inquire

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Description

BI-3406 (compound I-6) is a Son of Sevenless 1 (SOS1) inhibitor with an IC50 of 6 nM.

Biological activity

In Vitro BI-3406 is an inhibitor of the interaction between KRAS and its Guanine Nucleotide Exchange Factor (GEF) SOS1. BI-3406 does not block the interaction of KRAS with SOS2 but elicits activity on a broad panel of KRAS oncogenic variants, including all major G12 and G13 oncoproteins. Down-modulation of this signaling cascade by BI-3406 in KRAS G12 or G13 mutant cells effectively limits cell proliferation.

Identifiers

SMILES: CC1=NC(N[C@@H](C2=CC(C(F)(F)F)=CC(N)=C2)C)=C3C=C(O[C@@H]4COCC4)C(OC)=CC3=N1
InChIKey: XVFDNRYZXDHTHT-PXAZEXFGSA-N

Specifications

MW (average): 462.4648
Formula: C₂₃H₂₅F₃N₄O₃
CAS No.: 2230836-55-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO,Ethanol

Documents

References

[1]. Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.

[2]. Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.

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