SB-204990 free base · Synonyms: SB 204990 · SB204990

SB 204990 is a potent and specific inhibitor of ATP citrate lyase enzyme.

For research use only. Not for human or veterinary use.

Target ATP Citrate Lyase

Research area Metabolic Disease

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Data Sheet SDS COA

SB-204990 structure

CAS No.: 154566-12-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 450.00	BP-01898-50mg	In stock	Get quote
100 mg	USD 650.00	BP-01898-100mg	In stock	Get quote
250 mg	USD 1,150.00	BP-01898-250mg	In stock	Get quote
500 mg	USD 1,950.00	BP-01898-500mg	In stock	Get quote
1 g	USD 3,150.00	BP-01898-1g	In stock	Get quote

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Description

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

Biological activity

In Vitro SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels. In Vivo SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.

Identifiers

SMILES: C(C(O)=O)[C@@]1(O)C[C@@H](CCCCCCC2=C(Cl)C=C(Cl)C=C2)OC1=O
InChIKey: YTRNLFYTHYWDAU-KDOFPFPSSA-N

Specifications

MW (average): 389.2700
Formula: C₁₈H₂₂Cl₂O₅
CAS No.: 154566-12-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : ≥ 100 mg/mL H2O : 25 mg/mL

Documents

References

[1]. Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293(41):16019-16027.

[2]. Pearce NJ, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.

Same research area

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