Gemigliptin free base · Synonyms: LC15-0444
Gemigliptin is a highly selective, reversible and competitive dipeptidyl peptidase-4 inhibitor.
For research use only. Not for human or veterinary use.
Gemigliptin structure
CAS No.: 911637-19-9
Pack sizes & pricing
Description
Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4.
Biological activity
In Vitro Gemigliptin dose-dependently inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin dose-dependently suppressed the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin is a competitive inhibitor with a Ki of 7.25 nM[2]. In Vivo Gemigliptin (100 mg/kg; i.g.; daily; for 12 weeks) inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2].
Specifications
- MW (average)
- 489.3630
- Formula
- C18H19F8N5O2
- CAS No.
- 911637-19-9
- Physical state
- Solid
- Color
- white to orange
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO