TRAM 39 free base · Synonyms: TRAM-39 · TRAM39
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ channels.
For research use only. Not for human or veterinary use.
TRAM 39 structure
CAS No.: 197525-99-8
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 420.00 | BP-02436-50mg | In stock | Get quote |
| 100 mg | USD 670.00 | BP-02436-100mg | In stock | Get quote |
| 250 mg | USD 1,340.00 | BP-02436-250mg | In stock | Get quote |
| 500 mg | USD 2,150.00 | BP-02436-500mg | In stock | Get quote |
| 1 g | USD 3,440.00 | BP-02436-1g | In stock | Get quote |
| 2 g | Inquire | BP-02436-2g | In stock | Inquire |
| 3 g | Inquire | BP-02436-3g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .
Biological activity
In Vitro TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells. TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells. In Vivo TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations.
Identifiers
- SMILES
-
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl - InChIKey
-
JHNRTPKGSCVKKC-UHFFFAOYSA-N
Specifications
- MW (average)
- 303.7850
- Formula
- C20H14ClN
- CAS No.
- 197525-99-8
- Physical state
- Solid
- Color
- Off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- 4°C, sealed storage, away from moisture
Solubility
Soluble in DMSO : 50 mg/mL