CHR-2797 free base · Synonyms: Tosedostat

Tosedostat is an orally active aminopeptidase inhibitor.

For research use only. Not for human or veterinary use.

Target Aminopeptidase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CHR-2797 structure

CAS No.: 238750-77-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 425.00	BP-02514-100mg	In stock	Get quote
250 mg	USD 768.00	BP-02514-250mg	In stock	Get quote
500 mg	USD 1,372.00	BP-02514-500mg	In stock	Get quote
1 g	USD 2,425.00	BP-02514-1g	In stock	Get quote
2 g	Inquire	BP-02514-2g	In stock	Inquire

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Description

Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines .

Biological activity

Tosedostat (CHR2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, <1000, <5000, <10000 and <30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively. It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel.

Identifiers

SMILES: CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)C1=CC=CC=C1
InChIKey: FWFGIHPGRQZWIW-SQNIBIBYSA-N

Specifications

MW (average): 406.4727
Formula: C₂₁H₃₀N₂O₆
CAS No.: 238750-77-1
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year

Solubility

Soluble in DMSO

Documents

References

[1]. Harris PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem. 2017 Feb 23;60(4):1247-1261.

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