PCI-27483 free base · Synonyms: PCI 27483 · PCI27483

PCI-27483 is a FVIIa/tissue factor inhibitor.

For research use only. Not for human or veterinary use.

Target Factor VIIa

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

PCI-27483 structure

CAS No.: 871266-63-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 485.00	BP-02479-100mg	In stock	Get quote
250 mg	USD 970.00	BP-02479-250mg	In stock	Get quote
500 mg	USD 1,550.00	BP-02479-500mg	In stock	Get quote
1 g	USD 2,480.00	BP-02479-1g	In stock	Get quote
2 g	USD 3,970.00	BP-02479-2g	In stock	Get quote
3 g	USD 4,760.00	BP-02479-3g	In stock	Get quote
5 g	Inquire	BP-02479-5g	Inquire	Inquire

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Description

PCI-27483 is a FVIIa/tissue factor inhibitor, with antitumour effects.

Biological activity

In Vitro PCI-27483 inhibits the TF:FVIIa-complex induced phosphorylation of ERK1/2 and subsequent induction of c-fos in BxPC3 cells, a human pancreatic adenocarcinoma line that highly expresses TF. Furthermore, PCI-27483 blocks the TF:FVIIa induced secretion of IL8 in both BxPC3 cells and MDA-MB-231 breast cancer cells. In Vivo PCI-27483 shows dose-dependent inhibition of thrombus formation, fibrin accumulation and PT. PCI-27483 (4 mg/kg) shows comparable anticoagulation effects as 2 mg/kg enoxaparin[1]. PCI-27483 (0 and 90 mg/kg, s.c.) results in inhibition of tumor growth in CD1 nu/nu mice implanted with BxPC3 cells.

Identifiers

SMILES: NC(=N)C1=CC=C2N\C(NC2=C1)=C1\C=C(CC(=O)NC(CC(O)=O)C(O)=O)C=C(C1=O)C1=CC(=CC=C1O)S(N)(=O)=O
InChIKey: PVTVTDSZGJFYRP-PCLIKHOPSA-N

Specifications

MW (average): 596.5690
Formula: C₂₆H₂₄N₆O₉S
CAS No.: 871266-63-6
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year;

Solubility

Soluble in DMSO

Documents

References

[1]. Gómez-Outes A, et al. New parenteral anticoagulants in development. Ther Adv Cardiovasc Dis. 2011 Feb;5(1):33-59.

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