AR-C126313 free base

AR-C118925XX is a selective P2Y2 receptor antagonist.

For research use only. Not for human or veterinary use.

Target P2Y Receptor

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AR-C126313 structure

CAS No.: 216657-60-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 410.00	BP-02440-5mg	In stock	Get quote
10 mg	USD 660.00	BP-02440-10mg	In stock	Get quote
25 mg	USD 1,310.00	BP-02440-25mg	In stock	Get quote
50 mg	USD 2,100.00	BP-02440-50mg	In stock	Get quote
100 mg	USD 3,360.00	BP-02440-100mg	In stock	Get quote
250 mg	Inquire	BP-02440-250mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin -induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth .

Biological activity

In Vivo AR-C118925XX (i.p.) suppresses Bleomycin-enhanced dermal thickness in mice.

Identifiers

SMILES: O=C(C1=CC=C(CN2C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C53)C(NC2=O)=S)O1)NC6=NN=NN6
InChIKey: PVKNPGQAFNALOI-UHFFFAOYSA-N

Specifications

MW (average): 537.5920
Formula: C₂₈H₂₃N₇O₃S
CAS No.: 216657-60-2
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: -20°C, sealed storage, away from moisture

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Perera LMB, et al. The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor. J Invest Dermatol. 2019 Apr;139(4):890-899.

[2].Dong CR, et al. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. Carcinogenesis. 2022 Dec 5:bgac095.

Same research area

Search Inflammation/Immunology