BU 224 hydrochloride salt form · hydrochloride · Parent BU 224 hydrochloride

BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand.

For research use only. Not for human or veterinary use.

Target Imidazoline Receptor ApoptosisTNF Receptor

Research area Neurological Disease Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

BU 224 hydrochloride structure

CAS No.: 205437-64-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 350.00	BP-02397A-100mg	In stock	Get quote
250 mg	USD 700.00	BP-02397A-250mg	In stock	Get quote
500 mg	USD 1,120.00	BP-02397A-500mg	In stock	Get quote
1 g	USD 1,790.00	BP-02397A-1g	In stock	Get quote
2 g	USD 2,870.00	BP-02397A-2g	In stock	Get quote
3 g	USD 3,440.00	BP-02397A-3g	In stock	Get quote
5 g	USD 4,590.00	BP-02397A-5g	In stock	Get quote

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Description

BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3].

Biological activity

In Vivo BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice. BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice. BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity.

Identifiers

SMILES: C1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl
InChIKey: DDFHQXAQWZWRSQ-UHFFFAOYSA-N

Specifications

MW (average): 233.6970
Formula: C₁₂H₁₂ClN₃
CAS No.: 205437-64-5
Physical state: Solid
Color: Brown to gray
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light; In solvent -20°C, 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Mirzaei N, et al. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178(3):654-671.

[2]. Finn DP, et al. Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology (Berl). 2003 May;167(2):195-202.

[3]. Qiu Y, et al. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. Eur J Pharmacol. 2015 Feb 15;749:133-41.

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