BiochemProbe — Life Science Research Reagents

Chroman 1 free base · Synonyms: CHROMAN-1 · CHROMAN1

Chroman 1 is a highly potent and selective ROCK inhibitor.

For research use only. Not for human or veterinary use.

Target ROCK
Research area Cardiovascular Disease
Purity >98% Stock Inquire
Data Sheet SDS COA

Chroman 1 structure

CAS No.: 1273579-40-0

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
50 mg USD 550.00 BP-02380-50mg In stock Get quote
100 mg USD 750.00 BP-02380-100mg In stock Get quote
250 mg USD 1,298.00 BP-02380-250mg In stock Get quote
500 mg USD 2,190.00 BP-02380-500mg In stock Get quote
1 g Inquire BP-02380-1g In stock Inquire

Need another size or custom synthesis? Request a quote.

Description

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM.

Biological activity

In Vitro Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells

Identifiers

SMILES
O=C([C@@H]1COC2=CC=C(OC)C=C2C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C
InChIKey
ROFMCPHQNWGXGE-SFHVURJKSA-N

Specifications

MW (average)
436.5035
Formula
C24H28N4O4
CAS No.
1273579-40-0
Physical state
Solid
Color
White to pink
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro
DMSO : ≥ 50 mg/mL

Documents

References

[1]. Yu Chen, et al. A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells. bioRxiv 815761.
[2]. Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.

Same target

Search ROCK

Same research area

Search Cardiovascular Disease