AZD0095 free base · Synonyms: AZD-0095 · AZD 0095

AZD0095 is a selective and orally active MCT4 inhibitor.

For research use only. Not for human or veterinary use.

Target Monocarboxylate Transporter

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AZD0095 structure

CAS No.: 2750001-23-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 400.00	BP-02374-100mg	In stock	Get quote
250 mg	USD 700.00	BP-02374-250mg	In stock	Get quote
500 mg	USD 1,200.00	BP-02374-500mg	In stock	Get quote
1 g	USD 2,000.00	BP-02374-1g	In stock	Get quote
2 g	Inquire	BP-02374-2g	In stock	Inquire
5 g	Inquire	BP-02374-5g	In stock	Inquire

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Description

AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (EX-A2039).

Biological activity

In Vitro AZD0095 (0-50 µM) inhibits cell proliferation in NCI-H358 cells (high expression of MCT4), with an IC50 of 26 nM. In Vivo AZD0095 (100 mg/kg, p.o. bid) together with Cediranib (3 mg/kg, p.o.) reduces tumor growth in a murine NCI-H358 xenograft.

Identifiers

SMILES: CC1=C(O[C@H]2CN(C3=CC=C(C4=NN=C(CN5CCOCC5)C=C4)C=C3)CC2)C(C)=NC6=NC(C)=NN16
InChIKey: PHDAGSZQGNWGFE-XMMPIXPASA-N

Specifications

MW (average): 500.5954
Formula: C₂₇H₃₂N₈O₂
CAS No.: 2750001-23-9
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 10 mg/mL

Documents

References

[1]. Goldberg FW, et al. Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. J Med Chem. 2022 Dec 16.

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