DS-9300 free base · Synonyms: DS 9300 · DS9300

DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor.

For research use only. Not for human or veterinary use.

Target Histone Acetyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

DS-9300 structure

CAS No.: 2259641-46-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 598.00	BP-02372-100mg	In stock	Get quote
250 mg	USD 998.00	BP-02372-250mg	In stock	Get quote
500 mg	USD 1,780.00	BP-02372-500mg	In stock	Get quote
1 g	USD 2,990.00	BP-02372-1g	In stock	Get quote
2 g	Inquire	BP-02372-2g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research .

Biological activity

In Vitro DS-9300 inhibits the growth of prostate cancer cell lines with the IC50 values of 0.6, 6.5, 3.4 and 287.2 nM for VCaP, 22Rv1, LNCaP and PC3 cells, respectively, indicating that it could effectively inhibit the growth of prostate cancer cell lines by inhibiting histone acetylation and down-regulating PSA expression In Vivo DS-9300 (p.o., 0.3-3 mg/kg, once daily, 33days) shows dose-dependent antitumor activity with 39%, 74% and 109% tumor growth inhibition at 0.3, 1 and 3 mg/kg, respectively, and no significant toxic effects in Castrated VCaP xenograft mouse model

Identifiers

SMILES: COC1=CC=C(C=C1)C2(CCC(F)(CC2)F)C(N3C[C@@H](C[C@@H]3C(NC4=NC5=C(NN=C5)C=C4)=O)F)=O
InChIKey: UCKDTCZSOLMOMQ-OXQOHEQNSA-N

Specifications

MW (average): 501.5008
Formula: C₂₅H₂₆F₃N₅O₃
CAS No.: 2259641-46-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1].Ryutaro Kanada, et al. Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor. J Med Chem. 2023 Jan 12;66(1):695-715.

Same target

Search Histone Acetyltransferase

Same research area

Search Cancer