BGJ-398 free base · Synonyms: NVP-BGJ398 | Infigratinib

Infigratinib phosphate is a potent inhibitor of the FGFR family.

For research use only. Not for human or veterinary use.

Target FGFR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BGJ-398 structure

CAS No.: 1310746-10-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 480.00	BP-02329-1g	In stock	Get quote
2 g	USD 798.00	BP-02329-2g	In stock	Get quote
5 g	USD 1,398.00	BP-02329-5g	In stock	Get quote
10 g	Inquire	BP-02329-10g	In stock	Inquire

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Description

Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

Biological activity

Identifiers

SMILES: OP(O)(O)=O.CCN1CCN(CC1)C1=CC=C(NC2=NC=NC(=C2)N(C)C(=O)NC2=C(Cl)C(OC)=CC(OC)=C2Cl)C=C1
InChIKey: GUQNHCGYHLSITB-UHFFFAOYSA-N

Specifications

MW (average): 658.4710
Formula: C₂₆H₃₄Cl₂N₇O₇P
CAS No.: 1310746-10-1
Physical state: Solid
Color: white to gray
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: <p>Powder 4°C, sealed storage, away from moisture</p> <p>*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)</p>

Solubility

Soluble in DMSO

Documents

References

[1]. Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T

[2]. Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42.

Same target

Search FGFR

Same research area

Search Cancer