Pyridostain free base

Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM).

For research use only. Not for human or veterinary use.

Target G-quadruplex

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Pyridostain structure

CAS No.: 1085412-37-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 460.00	BP-02314-100mg	In stock	Get quote
250 mg	USD 910.00	BP-02314-250mg	In stock	Get quote
500 mg	USD 1,450.00	BP-02314-500mg	In stock	Get quote
1 g	USD 2,330.00	BP-02314-1g	In stock	Get quote
2 g	USD 3,720.00	BP-02314-2g	In stock	Get quote
3 g	USD 4,470.00	BP-02314-3g	In stock	Get quote
5 g	Inquire	BP-02314-5g	In stock	Inquire
10 g	Inquire	BP-02314-10g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.

Biological activity

In Vitro Pyridostatin (RR82) (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin induces the formation of DNA DSBs. Remarkably, Pyridostatin (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.

Identifiers

SMILES: NCCOC1=CC(=NC(=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1
InChIKey: VGHSATQVJCTKEF-UHFFFAOYSA-N

Specifications

MW (average): 596.6364
Formula: C₃₁H₃₂N₈O₅
CAS No.: 1085412-37-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5.

[2]. Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28.

[3]. Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9(9):1957-1970.

Same research area

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