BiochemProbe — Life Science Research Reagents

NVP-BHG712 free base · Synonyms: BHG712

NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor.

For research use only. Not for human or veterinary use.

Target Ephrin Receptor
Research area Cancer
Purity >98% Stock Inquire
Data Sheet SDS COA

NVP-BHG712 structure

CAS No.: 940310-85-0

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
250 mg USD 440.00 BP-02298-250mg In stock Get quote
500 mg USD 700.00 BP-02298-500mg In stock Get quote
1 g USD 1,120.00 BP-02298-1g In stock Get quote
2 g USD 1,800.00 BP-02298-2g In stock Get quote
3 g USD 2,160.00 BP-02298-3g In stock Get quote
5 g USD 2,880.00 BP-02298-5g In stock Get quote
10 g Inquire BP-02298-10g In stock Inquire

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Description

NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC50 values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively.

Biological activity

In Vitro NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity. The data suggests a close cross talk between the VEGFR and EphR signaling during vessel formation. In Vivo NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis.

Identifiers

SMILES
CN1N=CC2=C(NC3=CC(=CC=C3C)C(=O)NC3=CC=CC(=C3)C(F)(F)F)N=C(N=C12)C1=CC=CN=C1
InChIKey
ZCCPLJOKGAACRT-UHFFFAOYSA-N

Specifications

MW (average)
503.4785
Formula
C26H20F3N7O
CAS No.
940310-85-0
Physical state
Solid
Color
White to yellow
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Tröster A, et al. NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem. 2018 Aug 20;13(16):1629-1633.
[2]. Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.

Same research area

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