Ingliforib free base · Synonyms: CP 368296 | GPi 296
Ingliforib is a glycogen phosphorylase inhibitor.
For research use only. Not for human or veterinary use.
Ingliforib structure
CAS No.: 186392-65-4
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 425.00 | BP-01939-50mg | In stock | Get quote |
| 100 mg | USD 625.00 | BP-01939-100mg | In stock | Get quote |
| 250 mg | USD 985.00 | BP-01939-250mg | In stock | Get quote |
| 500 mg | USD 1,485.00 | BP-01939-500mg | In stock | Get quote |
| 1 g | Inquire | BP-01939-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
Biological activity
In Vitro Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC50s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts. In Vivo Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.
Identifiers
- SMILES
-
O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N[C@@H](CC3=CC=CC=C3)[C@@H](O)C(N4C[C@@H](O)[C@@H](O)C4)=O - InChIKey
-
GVDRRZOORHCTAN-MJUUVYJYSA-N
Specifications
- MW (average)
- 457.9070
- Formula
- C23H24ClN3O5
- CAS No.
- 186392-65-4
- Physical state
- Solid
- Color
- light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO