Ingliforib free base · Synonyms: CP 368296 | GPi 296

Ingliforib is a glycogen phosphorylase inhibitor.

For research use only. Not for human or veterinary use.

Target Phosphorylase

Research area Cardiovascular Disease

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Data Sheet SDS COA

Ingliforib structure

CAS No.: 186392-65-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 425.00	BP-01939-50mg	In stock	Get quote
100 mg	USD 625.00	BP-01939-100mg	In stock	Get quote
250 mg	USD 985.00	BP-01939-250mg	In stock	Get quote
500 mg	USD 1,485.00	BP-01939-500mg	In stock	Get quote
1 g	Inquire	BP-01939-1g	In stock	Inquire

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Description

Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

Biological activity

In Vitro Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC50s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts. In Vivo Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.

Identifiers

SMILES: O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N[C@@H](CC3=CC=CC=C3)[C@@H](O)C(N4C[C@@H](O)[C@@H](O)C4)=O
InChIKey: GVDRRZOORHCTAN-MJUUVYJYSA-N

Specifications

MW (average): 457.9070
Formula: C₂₃H₂₄ClN₃O₅
CAS No.: 186392-65-4
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Tracey WR, et al. Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1177-84.

Same research area

Search Cardiovascular Disease