U-24969 free base · Synonyms: U 24969 · U24969

RU 24969 is a preferential 5-HT1B agonist.

For research use only. Not for human or veterinary use.

Target 5-HT Receptor

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

U-24969 structure

CAS No.: 66611-26-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 450.00	BP-02520-500mg	In stock	Get quote
1 g	USD 798.00	BP-02520-1g	In stock	Get quote
5 g	USD 2,998.00	BP-02520-5g	In stock	Get quote
10 g	Inquire	BP-02520-10g	In stock	Inquire

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Description

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion .

Biological activity

Identifiers

SMILES: COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1
InChIKey: KRVMLPUDAOWOGN-UHFFFAOYSA-N

Specifications

MW (average): 228.2896
Formula: C₁₄H₁₆N₂O
CAS No.: 66611-26-5
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : ≥ 30 mg/mL

Documents

References

[1].Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4.

[2].Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16.

Same target

Search 5-HT Receptor

Same research area

Search Neurological Disease