CZC-54252 free base · Synonyms: CZC 54252 · CZC54252

CZC-54252 is a potent and selective LRRK2 inhibitor.

For research use only. Not for human or veterinary use.

Target LRRK2

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

CZC-54252 structure

CAS No.: 1191911-27-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 698.00	BP-02511-500mg	In stock	Get quote
1 g	USD 1,298.00	BP-02511-1g	In stock	Get quote
2 g	USD 2,098.00	BP-02511-2g	In stock	Get quote
5 g	Inquire	BP-02511-5g	In stock	Inquire

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Description

CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity .

Biological activity

CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.

Identifiers

SMILES: COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2NS(C)(=O)=O)=N1)N1CCOCC1
InChIKey: CLGWUCNXOBLWFM-UHFFFAOYSA-N

Specifications

MW (average): 504.9900
Formula: C₂₂H₂₅ClN₆O₄S
CAS No.: 1191911-27-9
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C 3 years; 4°C 2 years. In solvent -20°C 1 year

Solubility

Soluble in DMSO

In vitro: DMSO : ≥ 100 mg/mL

Documents

References

[1].Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

Same target

Search LRRK2

Same research area

Search Neurological Disease