CZC-54252 free base · Synonyms: CZC 54252 · CZC54252
CZC-54252 is a potent and selective LRRK2 inhibitor.
For research use only. Not for human or veterinary use.
CZC-54252 structure
CAS No.: 1191911-27-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 500 mg | USD 698.00 | BP-02511-500mg | In stock | Get quote |
| 1 g | USD 1,298.00 | BP-02511-1g | In stock | Get quote |
| 2 g | USD 2,098.00 | BP-02511-2g | In stock | Get quote |
| 5 g | Inquire | BP-02511-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity .
Biological activity
CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.
Identifiers
- SMILES
-
COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2NS(C)(=O)=O)=N1)N1CCOCC1 - InChIKey
-
CLGWUCNXOBLWFM-UHFFFAOYSA-N
Specifications
- MW (average)
- 504.9900
- Formula
- C22H25ClN6O4S
- CAS No.
- 1191911-27-9
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C 3 years; 4°C 2 years. In solvent -20°C 1 year
Solubility
Soluble in DMSO
- In vitro
- DMSO : ≥ 100 mg/mL