CZC-54252 hydrochloride salt form · hydrochloride · Parent CZC-54252 hydrochloride
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor.
For research use only. Not for human or veterinary use.
Target
LRRK2
Research area
Neurological Disease
Purity >98%
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CZC-54252 hydrochloride structure
CAS No.: 1784253-05-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 290.00 | BP-02430A-100mg | In stock | Get quote |
| 250 mg | USD 580.00 | BP-02430A-250mg | In stock | Get quote |
| 500 mg | USD 930.00 | BP-02430A-500mg | In stock | Get quote |
| 1 g | USD 1,480.00 | BP-02430A-1g | In stock | Get quote |
| 2 g | USD 2,370.00 | BP-02430A-2g | In stock | Get quote |
| 3 g | USD 2,840.00 | BP-02430A-3g | In stock | Get quote |
| 5 g | USD 3,790.00 | BP-02430A-5g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity .
Identifiers
- SMILES
-
CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl - InChIKey
-
KWCBHUPLQMUKAF-UHFFFAOYSA-N
Specifications
- MW (average)
- 541.4510
- Formula
- C22H26Cl2N6O4S
- CAS No.
- 1784253-05-9
- Physical state
- Solid
- Color
- Light yellow to orange
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- 4°C, sealed storage, away from moisture
Solubility
Soluble in DMSO : 33.33 mg/mL
Documents
References
[1].Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.