NS2B/NS3-IN-3 hydrochloride salt form · hydrochloride · Parent NS2B/NS3-IN-3 hydrochloride

NS2B/NS3-IN-3 hydrochloride is an inhibitor of Flavivirus NS2B-NS3 protease.

For research use only. Not for human or veterinary use.

Target Virus Protease Flavivirus

Research area Infection

Purity >98% Stock Inquire

Data Sheet SDS COA

NS2B/NS3-IN-3 hydrochloride structure

CAS No.: 2832876-91-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 370.00	BP-02432A-100mg	In stock	Get quote
250 mg	USD 740.00	BP-02432A-250mg	In stock	Get quote
500 mg	USD 1,180.00	BP-02432A-500mg	In stock	Get quote
1 g	USD 1,890.00	BP-02432A-1g	In stock	Get quote
2 g	USD 3,030.00	BP-02432A-2g	In stock	Get quote
3 g	USD 3,637.00	BP-02432A-3g	In stock	Get quote
5 g	USD 4,850.00	BP-02432A-5g	In stock	Get quote

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Description

NS2B/NS3-IN-3 hydrochloride is an inhibitor of Flavivirus NS2B-NS3 protease, with an IC50 of 0.32 μM against Zika virus NS2B-NS3 protease. NS2B/NS3-IN-3 hydrochloride also exhibits inhibitory effects on dengue virus type 2 NS2B-NS3 protease and West Nile virus NS2B-NS3 protease. NS2B/NS3-IN-3 hydrochloride inhibits the intracellular replication of Zika virus. NS2B/NS3-IN-3 hydrochloride can be used in studies related to flavivirus infections .

Biological activity

In Vitro NS2B/NS3-IN-3 (compound 66) hydrochloride potently inhibits recombinant Zika virus NS2B-NS3 protease with an IC50 of 0.32 μM; it also inhibits recombinant dengue virus type 2 NS2B-NS3 protease with an IC50 of approximately 1-2 μM, and exhibits a non-competitive inhibition mode. NS2B/NS3-IN-3 (1-10 μM; 48 h) hydrochloride exhibits dose-dependent antiviral activity against Zika virus (strain FLR) in human U87 glioma cells, with an EC68 of 1 μM, and shows no toxicity to U87 cells at a concentration of 10 μM.

Identifiers

SMILES: O=C(C1=CC2=CC=C(C=C2N1)C3=COC=C3)NCC4CCNCC4.[H]Cl
InChIKey: ILKRKFAPUXCGDZ-UHFFFAOYSA-N

Specifications

MW (average): 359.8500
Formula: C₁₉H₂₂ClN₃O₂
CAS No.: 2832876-91-0
Physical state: Solid
Color: Orange to red
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light, stored under nitrogen; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Nie S, et al. Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease. European journal of medicinal chemistry. 2021 Dec 05;225:113767.

Same target

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Same research area

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