TC-G 1006 free base

S1P1 agonist III is an orally active hS1P1 agonist.

For research use only. Not for human or veterinary use.

Target LPL Receptor

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

TC-G 1006 structure

CAS No.: 1324003-64-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 420.00	BP-02422-100mg	In stock	Get quote
250 mg	USD 840.00	BP-02422-250mg	In stock	Get quote
500 mg	USD 1,340.00	BP-02422-500mg	In stock	Get quote
1 g	USD 2,150.00	BP-02422-1g	In stock	Get quote
2 g	USD 3,440.00	BP-02422-2g	In stock	Get quote
3 g	USD 4,130.00	BP-02422-3g	In stock	Get quote
5 g	Inquire	BP-02422-5g	In stock	Inquire

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Description

S1P1 agonist III is an orally active hS1P1 agonist with an EC50 value of 18 nM. S1P1 agonist III shows limited activity against hS1P3. S1P1 agonist III can be used in the research of multiple sclerosis .

Biological activity

In Vitro S1P1 agonist III (Compound 22) induces potent internalization of hS1P1 receptors in U2OS cells with an EC50 of 0.018 μM. S1P1 agonist III shows minimal agonist activity at hS1P3 receptors in transfected CHO-K1 cells, with an EC50 greater than 25 μM. S1P1 agonist III exhibits moderate permeability across LLC-PK1 porcine proximal tubule cells with no significant efflux, as shown by a Papp of 2.5 × 10-6 cm/s and an efflux ratio of 1.0. S1P1 agonist III binds to 91.7% of rat plasma proteins under equilibrium conditions. S1P1 agonist III is highly stable in rat liver microsomes, with an intrinsic clearance of less than 14 μL/min/mg microsomal protein. In Vivo S1P1 agonist III (Compound 22) (1-3 mg/kg; p.o.; single dose) produces statistically significant circulating blood lymphocyte reduction in female Lewis rats at 24 hours, with the 3 mg/kg dose causing an 88% reduction.

Identifiers

SMILES: COC1=CC=NC=C1C(NC(NC2=CC(C(F)(F)F)=C(C3=CC=CC=C3)C=C2)=O)=O
InChIKey: MLDQTQOMWDNTNN-UHFFFAOYSA-N

Specifications

MW (average): 415.3652
Formula: C₂₁H₁₆F₃N₃O₃
CAS No.: 1324003-64-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 62.5 mg/mL

Documents

References

[1].Harrington PE, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett. 2011;3(1):74-78. Published 2011 Nov 23.

Same target

Search LPL Receptor

Same research area

Search Inflammation/Immunology