NKY80 free base · Synonyms: NKY-80 · NKY 80

NKY80 is a potent, selective and non-competitive adenylyl cyclase type V isoform inhibitor.

For research use only. Not for human or veterinary use.

Target Adenylate Cyclase

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

NKY80 structure

CAS No.: 299442-43-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 400.00	BP-02415-50mg	In stock	Get quote
100 mg	USD 640.00	BP-02415-100mg	In stock	Get quote
250 mg	USD 1,280.00	BP-02415-250mg	In stock	Get quote
500 mg	USD 2,050.00	BP-02415-500mg	In stock	Get quote
1 g	USD 3,275.00	BP-02415-1g	In stock	Get quote
2 g	USD 5,240.00	BP-02415-2g	In stock	Get quote
3 g	Inquire	BP-02415-3g	In stock	Inquire

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Description

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .

Biological activity

In Vitro NKY80 (20 μM) blocks the elevations in both LVP and ventricular cAMP levels produced by the maximal concentration (10 nM). NKY80 (20 μM; 2 hours) completely blocks the increase in both cAMP content and renin release from isolated JG cells.

Identifiers

SMILES: O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1
InChIKey: SOJUSNIBPPMLCC-UHFFFAOYSA-N

Specifications

MW (average): 229.2346
Formula: C₁₂H₁₁N₃O₂
CAS No.: 299442-43-6
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 250 mg/mL

Documents

References

[1].Onda T, et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibitionof adenylyl cyclase isoforms. Biol Chem. 2001 Dec 21;276(51):47785-93.

[2].Harney JA, et al. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E155-61.

[3].Ortiz-Capisano MC, et al. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension. 2007 Mar;49(3):618-24.

Same research area

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