Lovastatin Diol Lactone free base

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

For research use only. Not for human or veterinary use.

Target HMG-CoA Reductase (HMGCR) Autophagy

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Lovastatin Diol Lactone structure

CAS No.: 79952-42-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 415.00	BP-02403-25mg	In stock	Get quote
50 mg	USD 664.00	BP-02403-50mg	In stock	Get quote
100 mg	USD 1,060.00	BP-02403-100mg	In stock	Get quote
250 mg	USD 2,125.00	BP-02403-250mg	In stock	Get quote
500 mg	USD 3,400.00	BP-02403-500mg	In stock	Get quote
1 g	USD 5,440.00	BP-02403-1g	In stock	Get quote
2 g	Inquire	BP-02403-2g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

Biological activity

In Vitro Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL.

Identifiers

SMILES: O=C1C[C@H](O)C[C@@H](CC[C@H]2[C@@H](C)C=CC3=C[C@H](C)C[C@H](O)[C@]23[H])O1
InChIKey: ZDFOBOYQVYMVCW-IRUSZSJRSA-N

Specifications

MW (average): 320.4232
Formula: C₁₉H₂₈O₄
CAS No.: 79952-42-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 2 month

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2.

Same target

Search HMG-CoA Reductase (HMGCR)

Same research area

Search Metabolic Disease