A-867744 free base · Synonyms: A 867744 · A867744
A-867744 is a highly potent and selective type II positive allosteric modulator of the alpha7 nicotinic acetylcholine receptors.
For research use only. Not for human or veterinary use.
A-867744 structure
CAS No.: 1000279-69-5
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 400.00 | BP-02381-100mg | In stock | Get quote |
| 250 mg | USD 600.00 | BP-02381-250mg | Inquire | Get quote |
| 500 mg | USD 900.00 | BP-02381-500mg | In stock | Get quote |
| 1 g | USD 1,485.00 | BP-02381-1g | In stock | Get quote |
| 2 g | Inquire | BP-02381-2g | In stock | Inquire |
| 5 g | Inquire | BP-02381-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.
Biological activity
A 867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Brain penetrant.
Identifiers
- SMILES
-
O=S(C1=CC=C(C=C1)N2C(C)=C(C=C2C3=CC=C(C=C3)Cl)C(CC)=O)(N)=O - InChIKey
-
ABACVOXFUHDKNZ-UHFFFAOYSA-N
Specifications
- MW (average)
- 402.8940
- Formula
- C20H19ClN2O3S
- CAS No.
- 1000279-69-5
- Physical state
- Solid
- Color
- White to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : ≥ 100 mg/mL