ASN90 free base · Synonyms: ASN-90 · ASN 90

ASN90 is a potent, selective, substrate-competitive O-GlcNAcase inhibitor.

For research use only. Not for human or veterinary use.

Target OGA Tau Protein

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

ASN90 structure

CAS No.: 1884154-02-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 598.00	BP-02367-50mg	In stock	Get quote
100 mg	USD 998.00	BP-02367-100mg	In stock	Get quote
250 mg	USD 1,785.00	BP-02367-250mg	In stock	Get quote
500 mg	Inquire	BP-02367-500mg	In stock	Inquire
1 g	Inquire	BP-02367-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM.

Biological activity

ASN90 is a specific and orally active O-GlcNAcase (OGA) enzyme inhibitor with IC50 value of 10.2 nM.

Identifiers

SMILES: CC(NC1=NN=C(N2CCN(CC2)[C@H](C3=CC=C(OCO4)C4=C3)C)S1)=O
InChIKey: PLUUAFJXXNCXSD-NSHDSACASA-N

Specifications

MW (average): 375.4450
Formula: C₁₇H₂₁N₅O₃S
CAS No.: 1884154-02-2
Physical state: Solid
Color: Light yellow to light brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Permanne, Bruno et al. “O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.” ACS chemical neuroscience vol. 13,8 (2022): 1296-1314.

Same target

Search OGA

Same research area

Search Neurological Disease