ICI 199441 hydrochloride salt form · hydrochloride · Parent ICI 199441 hydrochloride · Synonyms: ICI 199,441 hydrochloride
ICI-199441 hydrochloride is a potent and selective κ-opioid receptor agonist.
For research use only. Not for human or veterinary use.
Target
Opioid Receptor
Purity >98%
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ICI 199441 hydrochloride structure
CAS No.: 115199-84-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 585.00 | BP-02365A-250mg | In stock | Get quote |
| 500 mg | USD 990.00 | BP-02365A-500mg | In stock | Get quote |
| 1 g | USD 1,785.00 | BP-02365A-1g | In stock | Get quote |
| 2 g | Inquire | BP-02365A-2g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
ICI-199441 hydrochloride is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 hydrochloride can improve heart resistance to ischemia/reperfusion.
Biological activity
In Vivo ICI-199441 (Wistar rats, 0.1 mg/kg, IV, once) hydrochloride administered 15 min before ischemia produces a potent antiarrhythmic effect
Identifiers
- SMILES
-
O=C(N(C)[C@@H](C1=CC=CC=C1)CN2CCCC2)CC3=CC=C(Cl)C(Cl)=C3.Cl - InChIKey
-
VFLWVWZSDBTGQJ-VEIFNGETSA-N
Specifications
- MW (average)
- 427.7950
- Formula
- C21H25Cl3N2O
- CAS No.
- 115199-84-3
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 250 mg/mL
Documents
References
[1]. Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159(6):718-721.
[2]. Narita M, et al. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology. 2006 Apr;31(4):739-50.