Asundexian free base · Synonyms: BAY2433334

Asundexian is an orally active coagulation factor Xia inhibitor.

For research use only. Not for human or veterinary use.

Target Factor Xa

Research area Cardiovascular Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Asundexian structure

CAS No.: 2064121-65-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 520.00	BP-01965-100mg	In stock	Get quote
250 mg	USD 980.00	BP-01965-250mg	In stock	Get quote
500 mg	USD 1,580.00	BP-01965-500mg	In stock	Get quote
1 g	USD 2,580.00	BP-01965-1g	In stock	Get quote
5 g	Inquire	BP-01965-5g	Inquire	Inquire

Need another size or custom synthesis? Request a quote.

Description

Asundexian (BAY 2433334; BI1265162) is an orally active coagulation factor Xia (FXIa) inhibitor. BAY 2433334 inhibits human FXIa in buffer with an IC50 of 1 nM.

Biological activity

Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.

Identifiers

SMILES: O=C(N)C1=CC=C(NC([C@@H](N2C=C(OC)C(C3=CC(Cl)=CC=C3N4N=NC(C(F)(F)F)=C4)=CC2=O)CC)=O)C=C1F
InChIKey: XYWIPYBIIRTJMM-IBGZPJMESA-N

Specifications

MW (average): 592.9290
Formula: C₂₆H₂₁ClF₄N₆O₄
CAS No.: 2064121-65-7
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO ≥ 250 mg/mL

Documents

References

[1]. Thomas D, et al. First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa. J Thromb Haemost. 2021;19(10):2407-2416.

Same research area

Search Cardiovascular Disease