Valiltramiprosate free base · Synonyms: ALZ-801

ALZ-801 is a potent and orally available small-molecule β-amyloid anti-oligomer and aggregation inhibitor.

For research use only. Not for human or veterinary use.

Target Amyloid-β

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Valiltramiprosate structure

CAS No.: 1034190-08-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 880.00	BP-01831-1g	Inquire	Get quote
5 g	USD 2,650.00	BP-01831-5g	Inquire	Get quote
10 g	USD 4,250.00	BP-01831-10g	In stock	Get quote

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Description

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer's disease.

Biological activity

ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice

Identifiers

SMILES: O=S(CCCNC([C@@H](N)C(C)C)=O)(O)=O
InChIKey: NRZRFNYKMSAZBI-ZETCQYMHSA-N

Specifications

MW (average): 238.3050
Formula: C₈H₁₈N₂O₄S
CAS No.: 1034190-08-3
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture

Solubility

Soluble in H2O : 30 mg/mL

Documents

References

[1]. John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849–861.

[2]. Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333.

Same target

Search Amyloid-β

Same research area

Search Neurological Disease