ABBV-318 free base · Synonyms: ABBV 318 · ABBV318
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker.
For research use only. Not for human or veterinary use.
Target
Sodium Channel
Research area
Neurological Disease
Purity >98%
Stock Inquire
ABBV-318 structure
CAS No.: 1802848-94-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 685.00 | BP-02364-25mg | In stock | Get quote |
| 50 mg | USD 885.00 | BP-02364-50mg | In stock | Get quote |
| 100 mg | USD 1,185.00 | BP-02364-100mg | In stock | Get quote |
| 200 mg | USD 1,885.00 | BP-02364-200mg | In stock | Get quote |
| 500 mg | USD 2,885.00 | BP-02364-500mg | In stock | Get quote |
| 1 g | Inquire | BP-02364-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain.
Biological activity
ABBV-318 is a CNS-penetrating oral inhibitor of Nav1.7/Nav1.8 with IC50 values of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively, and is being developed for pain studies.
Identifiers
- SMILES
-
O=C(N1C[C@H](F)CC1)C2=NC3=CC=C(OC4=NC=C(C(F)(F)F)C=C4)C=C3C=C2 - InChIKey
-
FWLFRXVPNVBXGR-CQSZACIVSA-N
Specifications
- MW (average)
- 405.3456
- Formula
- C20H15F4N3O2
- CAS No.
- 1802848-94-7
- Physical state
- Solid
- Color
- White to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO 166.67 mg/mL
Documents
References
[1]. Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.