NBI-921352 free base · Synonyms: Zandatrigine | XEN901
Zandatrigine is a sodium channel protein type 8 subunit alpha blocker.
For research use only. Not for human or veterinary use.
NBI-921352 structure
CAS No.: 2154406-04-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 580.00 | BP-01976-250mg | In stock | Get quote |
| 500 mg | USD 928.00 | BP-01976-500mg | In stock | Get quote |
| 1 g | USD 1,485.00 | BP-01976-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker.
Biological activity
In Vitro Zandatrigine significantly inhibits persistent sodium current (INaP) in HEK293 cells expressing NaV1.6, with IC50 of 0.051 μM and 0.058 μM for hNaV1.6 and mNaV1.6, respectively; while the IC50 for hNaV1.1, hNaV1.2, mNaV1.1, and NaV1.2 are 39 μM, 6.9 μM, 709 μM, and 191 μM, respectively. In Vivo Zandatrigine (15 mg/kg; oral; single dose, 2 hours before electrical epilepsy induction) significantly reduces the incidence of electric shock-induced generalized tonic-clonic seizures (GTCs) in the Scn8aN1768D/+ gene mutant mouse model, with an ED50 of 15 mg/kg, with a positively correlated concentration in the brain with the therapeutic effect.
Identifiers
- SMILES
-
CN([C@@H]1CN(CC1)CC2=CC=CC=C2)C3=C(C=C(C(F)=C3)S(NC4=CSC=N4)(=O)=O)C - InChIKey
-
UCSHINHOAVARGQ-SFHVURJKSA-N
Specifications
- MW (average)
- 460.5880
- Formula
- C22H25FN4O2S2
- CAS No.
- 2154406-04-7
- Physical state
- Solid
- Color
- White to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 125 mg/mL