VAR10300 dihydrochloride salt form · dihydrochloride · Parent VAR10300 dihydrochloride

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A and MAO-B inhibitor.

For research use only. Not for human or veterinary use.

Target Monoamine Oxidase

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

VAR10300 dihydrochloride structure

CAS No.: 64821-19-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 450.00	BP-02265A-250mg	In stock	Get quote
500 mg	USD 768.00	BP-02265A-500mg	In stock	Get quote
1 g	USD 1,171.00	BP-02265A-1g	In stock	Get quote
5 g	Inquire	BP-02265A-5g	In stock	Inquire
10 g	Inquire	BP-02265A-10g	In stock	Inquire

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Description

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease .

Biological activity

In Vitro MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. In Vivo MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities

Identifiers

SMILES: CN(CC#C)CC1=C2C=CC=NC2=C(C=C1)O.Cl.Cl
InChIKey: XJNICPXVRPOSSO-UHFFFAOYSA-N

Specifications

MW (average): 299.1960
Formula: C₁₄H₁₆Cl₂N₂O
CAS No.: 64821-19-8
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, sealed storage, away from moisture; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 2 mg/mL

Documents

References

[1]. Gal S, et al. M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease. J Neural Transm Suppl. 2006;(70):447-456.

[2]. Zheng H, et al. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J Neurochem. 2005;95(1):68-78.

[3]. Gal S, et al. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion. J Neurochem. 2005;95(1):79-88.

[4]. Gal S, et al. Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30. Neurotox Res. 2010;17(1):15-27.

Same research area

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