BAY-6672 free base · Synonyms: BAY 6672 · BAY6672

BAY-6672 is a selective human prostaglandin F receptor antagonist.

For research use only. Not for human or veterinary use.

Target Prostaglandin Receptor

Research area Others

Purity >98% Stock Inquire

Data Sheet COA

BAY-6672 structure

CAS No.: 2247517-53-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 378.00	BP-01995-5mg	In stock	Get quote
10 mg	USD 548.00	BP-01995-10mg	In stock	Get quote
25 mg	USD 849.00	BP-01995-25mg	In stock	Get quote
50 mg	USD 1,235.00	BP-01995-50mg	In stock	Get quote
100 mg	USD 1,795.00	BP-01995-100mg	In stock	Get quote
250 mg	Inquire	BP-01995-250mg	In stock	Inquire
1 g	Inquire	BP-01995-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

BAY-6672 is a selective human prostaglandin F (FP) receptor antagonist that is highly potent (IC50=11 nM), orally available and well permeable. It exerts antifibrotic effects by inhibiting prostaglandin F2α (PGF₂α) activity through antagonizing the FP receptor, and has in vivo efficacy in animal models of idiopathic pulmonary fibrosis (IPF).

Biological activity

In vivo Anti-fibrotic activity of BAY-6672 (3, 10, 30 mg/kg, twice daily) in a 10-day silica-induced pulmonary fibrosis model in mice. Significant reductions in relevant profibrotic and inflammatory biomarkers, including the cytokines IL-1 and MCP-1, and the ECM protein osteopontin (OPN), were observed.

Identifiers

SMILES: BrC(C=C1)=CC2=C1N=C(N3CCCC3)C(C)=C2C(NC[C@H](CCC(O)=O)C4=CC=CC=C4Cl)=O
InChIKey: YQOLEILXOBUDMU-KRWDZBQOSA-N

Specifications

MW (average): 544.8680
Formula: C₂₆H₂₇BrClN₃O₃
CAS No.: 2247517-53-7
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Documents

References

[1]. Beck H, et al. Potent and Selective Human Prostaglandin F (FP) Receptor Antagonist (BAY-6672) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF). J Med Chem. 2020 Oct 22;63(20):11639-11662.

Same target

Search Prostaglandin Receptor

BP-01877 E-7046 free base · >98%

Same research area

Search Others