AM281 free base · Synonyms: AM-281 · AM 281
AM281 is a selective CB1 receptor antagonist.
For research use only. Not for human or veterinary use.
AM281 structure
CAS No.: 202463-68-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 898.00 | BP-02496-50mg | In stock | Get quote |
| 100 mg | USD 1,498.00 | BP-02496-100mg | In stock | Get quote |
| 250 mg | USD 2,698.00 | BP-02496-250mg | In stock | Get quote |
| 500 mg | Inquire | BP-02496-500mg | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM .
Biological activity
In Vitro AM281 (0.01-10 μM) promotes a concentration dependent increase in 10 μM Aβ 25-35 induced neurotoxicity in SH-SY5Y cells in the presence of 10 μM KSO 1-6. In Vivo Acute administration (2.5, 5 and 10 mg/kg) of AM281 shortens exploration time and improves memory performance, as does chronic administration (0.62, 1.25 and 2.5 mg/kg) of AM281. Chronic administration of AM281 at 2.5 mg/kg improves recognition index to the 22.1±4.8 and single dose of AM281 at 5 mg/kg improves the memory impairment to the 8.5±4, as compared with vehicle-treated which is 4.8±2.5. Administration of AM281 at a dose of 2.5 mg/kg in chronic form and 5 mg/kg in acute dose improve memory.
Identifiers
- SMILES
-
CC1=C(N(N=C1C(=O)NN1CCOCC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(I)C=C1 - InChIKey
-
AJFFBPZYXRNAIC-UHFFFAOYSA-N
Specifications
- MW (average)
- 557.2120
- Formula
- C21H19Cl2IN4O2
- CAS No.
- 202463-68-1
- Physical state
- Solid
- Color
- White to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO, not in water