BuChE-IN-TM-10 free base · Synonyms: TM-10
BuChE-IN-TM-10 is a potent butyrylcholinesterase inhibitor.
For research use only. Not for human or veterinary use.
Target
Cholinesterase (ChE)
Research area
Neurological Disease
Purity >98%
Stock Inquire
BuChE-IN-TM-10 structure
CAS No.: 2313524-95-5
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 698.00 | BP-02000-25mg | In stock | Get quote |
| 50 mg | USD 978.00 | BP-02000-50mg | In stock | Get quote |
| 100 mg | USD 1,369.00 | BP-02000-100mg | In stock | Get quote |
| 250 mg | USD 2,065.00 | BP-02000-250mg | In stock | Get quote |
| 500 mg | Inquire | BP-02000-500mg | In stock | Inquire |
| 1 g | Inquire | BP-02000-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer's disease.
Identifiers
- SMILES
-
COC(C=C1/C=C/C(N2CC3=CC=CC=C3CC2)=O)=C(C=C1)OCCCCN(CC)CC4=CC=CC=C4 - InChIKey
-
CGZGXSZYVAXOGJ-FBMGVBCBSA-N
Specifications
- MW (average)
- 498.6557
- Formula
- C32H38N2O3
- CAS No.
- 2313524-95-5
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
Documents
References
[1]. Sang Z, et al. Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2019 Feb 20;10(2):1008-1024.