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Quetiapine sulfoxide dihydrochloride salt form · dihydrochloride · Parent Quetiapine sulfoxide dihydrochloride

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem.

For research use only. Not for human or veterinary use.

Research area Neurological Disease
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Quetiapine sulfoxide dihydrochloride structure

CAS No.: 329218-11-3

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
100 mg USD 598.00 BP-01702A-100mg In stock Get quote
250 mg USD 998.00 BP-01702A-250mg In stock Get quote
500 mg USD 1,798.00 BP-01702A-500mg In stock Get quote
1 g Inquire BP-01702A-1g In stock Inquire
2 g Inquire BP-01702A-2g In stock Inquire

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Description

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic . Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist .

Biological activity

In Vivo The Cmax value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUClast value is estimated for Quetiapine sulfoxide (1,286±458 ng•h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing

Identifiers

SMILES
OCCOCCN(CC1)CCN1C2=NC(C=CC=C3)=C3S(C4=C2C=CC=C4)=O.Cl[H].Cl[H]
InChIKey
MPRQQJUQOLNAFP-UHFFFAOYSA-N

Specifications

MW (average)
472.4280
Formula
C21H27Cl2N3O3S
CAS No.
329218-11-3
Physical state
Solid
Color
White to yellow
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month;

Solubility

Soluble in H2O

In vitro
H2O : 233.33 mg/mL

References

[1]. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537.
[2]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.

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