JNJ 5207852 free base · Synonyms: JNJ-5207852 · JNJ5207852
JNJ-5207852 is a selective and potent histamine H3 receptor antagonist.
For research use only. Not for human or veterinary use.
JNJ 5207852 structure
CAS No.: 398473-34-2
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 480.00 | BP-02126-100mg | In stock | Get quote |
| 250 mg | USD 945.00 | BP-02126-250mg | In stock | Get quote |
| 500 mg | USD 1,516.00 | BP-02126-500mg | In stock | Get quote |
| 1 g | USD 2,380.00 | BP-02126-1g | In stock | Get quote |
| 2 g | USD 3,800.00 | BP-02126-2g | In stock | Get quote |
| 3 g | USD 4,500.00 | BP-02126-3g | In stock | Get quote |
| 5 g | Inquire | BP-02126-5g | In stock | Inquire |
| 10 g | Inquire | BP-02126-10g | In stock | Inquire |
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Description
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
Biological activity
n Vivo JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels.
Identifiers
- SMILES
-
C(COC1=CC=C(CN2CCCCC2)C=C1)CN1CCCCC1 - InChIKey
-
PTKHFRNHJULJKT-UHFFFAOYSA-N
Specifications
- MW (average)
- 316.4809
- Formula
- C20H32N2O
- CAS No.
- 398473-34-2
- Physical state
- Solid
- Color
- Light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO