Lanifibranor free base · Synonyms: IVA337

Lanifibranor is a pan peroxisome proliferator-activated receptor agonist.

For research use only. Not for human or veterinary use.

Purity >98% Stock Inquire

Data Sheet SDS COA

Lanifibranor structure

CAS No.: 927961-18-0

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 598.00	BP-02105-100mg	In stock	Get quote
250 mg	USD 1,198.00	BP-02105-250mg	In stock	Get quote
500 mg	USD 1,998.00	BP-02105-500mg	In stock	Get quote
1 g	Inquire	BP-02105-1g	In stock	Inquire

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Description

Lanifibranor is a pan peroxisome proliferator-activated receptor (PPAR) agonist with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively.

Identifiers

SMILES: OC(=O)CCCC1=CC2=C(C=CC(Cl)=C2)N1S(=O)(=O)C1=CC=C2N=CSC2=C1
InChIKey: OQDQIFQRNZIEEJ-UHFFFAOYSA-N

Specifications

MW (average): 434.9160
Formula: C₁₉H₁₅ClN₂O₄S₂
CAS No.: 927961-18-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO: 50 mg/ml

Documents

References

[1]. Boubia B, et al. Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. J Med Chem. 2018 Feb 27.

[2]. Ruzehaji N, et al. Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis. Ann Rheum Dis. 2016 Dec;75(12):2175-2183.