Safety Data Sheet

Avapritinib Safety Data Sheet (SDS) CAS 1703793-34-3

Catalog No. BP-01923 · Physical form Solid · Version 1.1 · Revision 2026-09-03

For research use only. Not for human or veterinary use.

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Section 1 — Identification

Product name: Avapritinib
Catalog number: BP-01923
CAS number: 1703793-34-3
Recommended use: Laboratory research chemical
Supplier: Guangzhou Yuyuan Biotech Co., Ltd. (BiochemProbe) · Baiyun District, Guangzhou, Guangdong, China
Telephone / Fax: +86 20 31130026 / +86 20 36822386
Email / Web: [email protected] · www.biochemprobe.com

Section 2 — Hazard(s) identification

GHS classification

Skin irritation — Category 2
Eye irritation — Category 2A
Specific target organ toxicity, single exposure — Category 3 (respiratory tract irritation)

Signal word: Warning
Pictogram: GHS07
Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.
Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P302+P352 IF ON SKIN: Wash with plenty of water. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P501 Dispose of contents/container to an approved waste disposal plant.
Additional notes: Dust may form an irritant atmosphere if handled without local exhaust.

Section 3 — Composition / information on ingredients

Chemical name: Avapritinib
Synonyms: Blu-285
Molecular formula: C₂₆H₂₇FN₁₀
Molecular weight: 498.5580
CAS number: 1703793-34-3

Section 4 — First-aid measures

Inhalation: Move to fresh air. If breathing is difficult, give oxygen. Seek medical attention if symptoms persist.

Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical advice if irritation develops.

Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

Ingestion: Rinse mouth. Do NOT induce vomiting. Call a poison center or physician if you feel unwell.

Section 5 — Fire-fighting measures

Suitable extinguishing media: Water spray, dry chemical, carbon dioxide, or alcohol-resistant foam
Unsuitable media: Do not use a solid water stream that may scatter dust
Specific hazards: May emit toxic fumes under fire conditions

Section 6 — Accidental release measures

Personal precautions: Wear suitable PPE (Section 8). Ensure adequate ventilation. Avoid dust formation.

Environmental precautions: Prevent entry into drains and surface water.

Cleanup: Sweep or vacuum carefully (HEPA preferred). Place in a suitable closed container for disposal.

Section 7 — Handling and storage

Handling: Handle in a well-ventilated area or fume hood. Avoid contact with skin and eyes. Do not eat, drink, or smoke when using this product.

Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Incompatibilities: Strong oxidizing agents (general guidance). Keep away from food and feed.

Section 8 — Exposure controls / personal protection

Occupational exposure limits: No specific OELs established for this substance
Engineering controls: Local exhaust / laboratory fume hood
Eye / face / skin: Safety glasses with side shields or chemical goggles; chemical-resistant gloves (e.g. nitrile); lab coat
Respiratory protection: If dust is generated, use approved particulate respirator

Section 9 — Physical and chemical properties

Appearance: White to light yellow solid
Physical state: Solid
Color: White to light yellow
Solubility: Soluble in DMSO

Section 10 — Stability and reactivity

Chemical stability: Stable under recommended storage conditions
Conditions to avoid: Moisture, excessive heat, dust generation
Incompatible materials: Strong oxidizers

Section 11 — Toxicological information

Likely routes of exposure: Inhalation of dust, skin and eye contact, ingestion.

Acute toxicity: See Section 2. Substance-specific LD50/LC50 data not available.
Skin corrosion / irritation: See Section 2.
Serious eye damage / irritation: See Section 2.
Respiratory or skin sensitization: No data available.
Germ cell mutagenicity: No data available.
Carcinogenicity: No data available. No component present at ≥0.1% is identified as a probable, possible, or confirmed human carcinogen by IARC, NTP, or OSHA based on available data.
Reproductive toxicity: No data available.
STOT — single exposure: See Section 2.
STOT — repeated exposure: No data available.
Aspiration hazard: Not applicable for solid under normal use.

Additional information: To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Treat as a research chemical.

Section 12 — Ecological information

No specific ecotoxicity data available. Do not release to the environment.

Section 13 — Disposal considerations

Dispose of contents/container in accordance with local, regional, and national regulations.

Section 14 — Transport information

DOT (US): Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Special precautions: Transport in sealed containers; protect from moisture / leakage

Section 15 — Regulatory information

Intended for research use only. Determine applicability of local chemical inventory listings and workplace regulations before use.

Section 16 — Other information

SDS version: 1.1
Revision date: 2026-09-03

The information provided is summarized for reference only. For official regulation, archival, customs, or audit use, download the certified PDF when published. Information is believed accurate but is provided without warranty. Recipients must verify suitability for intended use and regulatory obligations.