Arcyriaflavin A free base
Arcyriaflavin A is an indolo[2,3-a]carbazole compound and also a cyclin D1/CDK4 inhibitor.
For research use only. Not for human or veterinary use.
Arcyriaflavin A structure
CAS No.: 118458-54-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 420.00 | BP-00561-50mg | In stock | Get quote |
| 100 mg | USD 798.00 | BP-00561-100mg | In stock | Get quote |
| 250 mg | USD 1,398.00 | BP-00561-250mg | In stock | Get quote |
| 500 mg | Inquire | BP-00561-500mg | In stock | Inquire |
| 1 g | Inquire | BP-00561-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Arcyriaflavin A is an indolo[2,3-a]carbazole compound and also a cyclin D1/CDK4 inhibitor. Arcyriaflavin A exists in the marine ascidian Eudistoma sp. and the slime mold Arcyria denudata. Arcyriaflavin A is applicable to research related to colon cancer and lung cancer .
Biological activity
Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM). Also active against CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM).
Identifiers
- SMILES
-
O=C1NC(C2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6)=O - InChIKey
-
KAJXOWFGKYKMMZ-UHFFFAOYSA-N
Specifications
- MW (average)
- 325.3202
- Formula
- C20H11N3O2
- CAS No.
- 118458-54-1
- Physical state
- Solid
- Color
- Brown to reddish brown
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 25 mg/mL